Abstract: This study aims to investigate the high velocity impact resistance characteristics of fiber-reinforced origami sandwich plates by adopting a combination of theory and experiment. First, based on the ABAQUS software and comprehensively considering the constitutive relationship and material characteristics of the plates and core layer as well as different failure criteria of various materials, a finite element model for high-speed impact of this new sandwich structure was created, and the solutions for key impact parameters such as structural impact area and residual velocity of the projectile were obtained. Further, by employing the data, such as the damage mode and damage area of such a structure, and the residual velocity and critical velocity of the projectile obtained from literature and experiments, the effectiveness of the developed finite element model and its prediction results were proved. It can be found that the composite plates of such a structure will happen to the problems with high velocity impact, including fiber tearing, fiber delamination, and matrix rupture. Also, the origami core layer will rupture and separate from the panel material. However, by comparing the residual velocity curves of the projectile at different initial velocities, it can be known that the embedded shear-hardening materials can well improve the impact resistance of the structure.