Abstract: Porous functional materials have received increasing attention in fields such as gas storage, biopharmaceuticals and other environmental sciences. Among them, hydrogen-bonded organic frameworks (HOFs), which are self-assembled from organic or metal-organic skeletons through intermolecular hydrogen bonding, have been widely valued because of their well-defined structures, mild synthesis conditions, and ease of functional loading, etc. HOFs can be tailored to meet the needs of different applications by rationally selecting organic framework molecules and adjusting the hydrogen bonding motifs, and the hydrogen bonding energies are weaker than those of metal-organic skeletons (MOFs) and covalent skeletons (COFs). The hydrogen bonding energy in HOFs is weaker than the covalent and coordination bonds in metal-organic frameworks (MOFs) and covalent frameworks (COFs), but they still have flexible assembly properties similar to MOFs and COFs, which has stimulated the interest of researchers in various fields. In this paper, we mainly introduce the synthesis methods and principles of four typical HOFs represented by diaminotriazine (DAT), carboxylic acid (—COOH),sulfonic acid(—SO₃H) and pyrazole (C₃H₄N₂), and discuss the latest progress of HOFs in the fields of gas separation, multiphase catalysis, and electrochemical applications from the perspective of applications, focusing on their application stability, proton conduction, catalysis , ion sieving and electrochemical energy storage. In addition, we review the current opportunities and challenges in the application of HOFs to provide an effective reference for broadening the application areas of functional topological porous materials.