炭纤维增强羟基磷灰石/聚乳酸复合生物材料的力学性能和体外降解性能
Mechanical properties and degradation properties in vitro of carbon fiber reinforced hydroxyapatite/polylactide composite
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摘要: 采用溶液共混法制备了炭纤维(CF)增强羟基磷灰石(HA)/聚乳酸(PLA)三元复合生物材料。研究了该复合材料的力学性能和体外降解性能。CF/HA/PLA复合材料具有优异的力学性能, 弯曲强度和弯曲模量均随着HA含量的增加先升高后降低, 存在一个峰值, 可分别达到430MPa和26GPa。在PBS模拟体液中降解3个月, 弯曲强度和弯曲模量分别下降到初始值的30%和36%。SEM照片显示, 降解是从复合材料的界面开始的, 降解3个月后, 界面结合处出现缝隙, 吸水率增加到5%, 质量损失只有1.6%。PBS模拟体液的pH值下降在0.1之内, 有利于骨折部位的愈合。实验结果表明, 该复合材料的机械性能满足骨折内固定材料技术指标的要求。Abstract: A novel composite of carbon fiber (CF) reinforced hydroxyapatite (HA)/ploylactide (PLA) degradable biomaterial was developed by solvent blending. The mechanical properties and degradation properties in vitro of the composite were researched. The CF/HA/PLA composites have excellent mechanical properties. As the hydroxyapatite mass fraction increases, there are respectively peak values with flexural strength and flexural modulus, including maximums of flexural strength of 430MPa and flexural modulus of 26GPa. After degradating in vitro for 3 months, the flexural strength and flexural modulus fall 30% and 36% respectively. The SEM photos indicate that the degradation begins from the interfaces of the composite, after degradating, there are gaps at the interfaces, and the water uptake increases to 5%, but the mass loss is only 1.6%. The pH values of the PBS drop less than 0.1, which can do some favors to the recoveries of the fracture. The results show that the mechanical properties of the composite can meet the requirements of internal fracture fixation.