壳聚糖/磷灰石-硅灰石复合多孔支架材料的制备与性能

Preparation and properties of the CS/AW composite as porous scaffold material

  • 摘要: 以磷灰石-硅灰石(AW)生物活性多孔玻璃陶瓷支架材料为基体,采用物理包被法制备了壳聚糖(CS)/AW复合多孔支架材料,通过红外图谱分析、扫描电镜、光学显微镜、强度检测等分析测试方法,研究了复合材料的组成、微观结构、力学和矿化性能。结果发现:复合材料与AW多孔支架材料基体相比,仍具有三维贯通且分布均匀的孔隙结构,孔径尺寸约 100~500μm,孔隙率为80%左右,且力学性能明显增强,平均抗压强度可达3.11 MPa,比多孔AW支架材料基体的平均抗压强度提高了8.3倍。体外模拟体液浸泡实验表明,复合材料具有较高的矿化功能,预示材料具有较好的生物活性。这种复合材料可望作为人体非承重部位的植入骨修复体和组织工程支架使用。

     

    Abstract: The chitosan (CS)/apatite-wollastonite (AW) composite porous scaffold material was prepared with AW porous glass ceramic as matrix,being coated with CS. The composition,microstructure,mechanical and mineralizing properties of the composite materials were studied by means of FRIT,SEM,optical microscope and strength testing. The results show that the composite materials still have three dimensional and interconnective as well as uniformly distributed porous structure,the diameters of pores range from 100μm to 500μm,the porosity of the composite is about 80%,and the mechanical properties of the composite materials are increased greatly,the average compressive strength being 3.11 MPa,8.3 times that of the AW scaffold material. The in vitro simulated body fluid (SBF) soaking shows that the composite materials have high mineralization function,and indicates that they also have good bioactivity. This composite is a promising material for tissue engineering scaffold materials and non-load bearing bone implants.

     

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