Abstract: Skin scalds easily cause bacterial infection and excessive inflammatory responses, which delay wound healing. Traditional medical gauzes suffer from weak antibacterial activity and insufficient repair-promoting capacity. In this study, a hydrogel was fabricated using quaternized chitosan as the matrix with the incorporation of silane coupling agent and itaconic acid, and a multifunctional composite antibacterial gauze was prepared by loading ginger extract into the hydrogel. The microstructure and chemical composition of the composite gauze were characterized via SEM, FTIR and EDS tests. The antibacterial performance was evaluated through inhibition zone observation, viable bacterial counting and bacterial morphological analysis. The biocompatibility was assessed by MTT assay and live/dead cell staining. A rat scald infection model was established to explore the wound healing mechanism by detecting wound closure rate, performing H&E and Masson staining of wound tissues, and analyzing the expression of inflammatory factors. The results show that the composite gauze possesses a compact cross-linked structure. It achieves an antibacterial rate of over 99% against E. coli and S.aureus, and maintains a cell survival rate of more than 90%. In vivo animal experiments verify that the composite gauze can downregulate the expression of IL-1β and TNF-α inflammatory factors, promote the growth of granulation tissue and collagen deposition, and realize a wound closure rate of 84.94% on the 14th day. With excellent antibacterial, anti-inflammatory properties and high biocompatibility, the composite gauze provides a novel research idea and application basis for the development of medical dressings for scald wound treatment.