Abstract: Vascular self-lubrication epoxy resin (VAEP) and carbon fiber (CF)/VAEP composites were prepared by the vaporization of sacrificial components (VaSC) technology and vacuum immerse mode. With methyl silicone oil as a lubricant, polylactide (PLA) was used as the sacrificial components, CF was used as the reinforcing components, which was woven into PLA-CF fabric by the measure of warp and weft weave. The morphology of the CF/VAEP composites of section, friction surface and transfer film surface were characterized by SEM. The mechanical properties and tribological properties of the CF/VAEP composites were tested by electronic universal testing machine and high-speed block-on-ring wear tester. The results show that the vascular structure and CF enhance the lubrication and mechanical properties of epoxy resin (EP). Compared with the pure EP, when the radial direction vascular density of the VAEP is 8 pores/10 mm, the friction coefficient and wear rate are reduced by 67.95% and 85.71%, respectively. Compared with the same radial direction vascular density of VAEP, when the radial direction vascular density of the CF/VAEP composites is 8 pores/10 mm and warp to weft ratio of CF tow is 8/4, the tensile strength, tensile modulus, bending strength and bending modulus of the CF/VAEP vascular self-lubricating composites are increased by 203.33%, 44.16%, 325.78%, 311.37%, respectively.