Fabrication and properties of porous ZnO/hydroxyapatite biocomposites
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摘要: 利用放电等离子烧结技术制备多孔ZnO/羟基磷灰石(HA)生物复合材料,研究不同纳米ZnO含量对ZnO/HA复合材料微观结构、孔隙特征、力学性能、矿化和降解性能的影响。结果表明:烧结后ZnO/HA复合材料主要由HA相和ZnO相组成;随着ZnO含量提高,多孔ZnO/HA复合材料孔隙率缓慢增大,抗压强度略有减小,弹性模量变化不大;多孔ZnO/HA复合材料的孔隙率>40%,孔径在50~500 μm之间,抗压强度>148 MPa,弹性模量为6.5 GPa左右,能够满足骨修复材料的要求;模拟人工体液中矿化和降解实验表明,多孔ZnO/HA复合材料浸泡7天后表面开始形成大量类骨磷灰石层,且随着ZnO含量增加,磷灰石形成能力明显增强而降解速率加快。Abstract: The porous ZnO/hydroxyapatite (HA) biological composites were prepared by spark plasma sintering (SPS) technology. The effects of different nano ZnO contents on the microstructure, pore characteristics, mechanical properties, mineralization and degradation of the ZnO/HA composites were studied. The results show that the sintered ZnO/HA composites are mainly composed of HA phases and ZnO phases. With increasing of ZnO content, the porosity of the ZnO/HA composites increases slowly, the compressive strength decreases slowly, and the elastic modulus does not change much. The ZnO/HA composites have the porosity>40%, pore diameter of 50-500 μm, compressive strength>148 MPa, elastic modulus about 6.5 GPa, which can meet the requirements of bone repair materials. The mineralization and degradation experiments in simulated artificial body fluids show that a large number of osteoid apatite layers are formed on the surface of the ZnO/HA composite after soaking for 7 days. Furthermore, the apatite formation ability of the ZnO/HA composites is significantly enhanced and the degradation rate of the composites is increased with increasing of ZnO content.
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