Preparation and characterization of Basil essential oil nanoparticles/polyvinylpyrrolidone-polyvinyl alcohol hydrogel wound dressing

XU Mi; ZHANG Liang; HE Zhixian

doi:10.13801/j.cnki.fhclxb.20230629.002

Volume 41 Issue 2

Feb. 2024

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XU Mi, ZHANG Liang, HE Zhixian. Preparation and characterization of Basil essential oil nanoparticles/polyvinylpyrrolidone-polyvinyl alcohol hydrogel wound dressing[J]. Acta Materiae Compositae Sinica, 2024, 41(2): 748-760. doi: 10.13801/j.cnki.fhclxb.20230629.002

Citation:

XU Mi, ZHANG Liang, HE Zhixian. Preparation and characterization of Basil essential oil nanoparticles/polyvinylpyrrolidone-polyvinyl alcohol hydrogel wound dressing[J]. Acta Materiae Compositae Sinica, 2024, 41(2): 748-760. doi: 10.13801/j.cnki.fhclxb.20230629.002

Citation:

XU Mi, ZHANG Liang, HE Zhixian. Preparation and characterization of Basil essential oil nanoparticles/polyvinylpyrrolidone-polyvinyl alcohol hydrogel wound dressing[J]. Acta Materiae Compositae Sinica, 2024, 41(2): 748-760. doi: 10.13801/j.cnki.fhclxb.20230629.002

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Preparation and characterization of Basil essential oil nanoparticles/polyvinylpyrrolidone-polyvinyl alcohol hydrogel wound dressing

doi: 10.13801/j.cnki.fhclxb.20230629.002

XU Mi¹,
ZHANG Liang^{1
,
,},
HE Zhixian²

1.
School of Chemistry and Chemical Engineering, Xi'an University of Architecture and Technology, Xi'an 710311, China
2.
Analysis and Test Center, Xi'an University of Architecture and Technology, Xi'an 710311, China

Funds: National Natural Science Foundation of China (51874223)

Received Date: 2023-04-25
Accepted Date: 2023-06-15
Rev Recd Date: 2023-05-31

Available Online: 2023-06-30

Publish Date: 2024-02-01

Abstract

Abstract

Basil essential oil (BEO) is a green and safe antibacterial agent. However, the high volatility of BEO has limited its application in the field of antibacterial wound dressings. BEO nanoparticles (BEO@Zein) were prepared by nanoprecipitation method. They were then loaded on the hydrogel based on polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) to form BEO@Zein/PVP-PVA hydrogel wound dressing by freeze-thaw cycle. The microscopic morphology and structure of BEO@Zein and hydrogel were characterized. The antibacterial property, mechanical property, swelling and moisturizing, degradability and blood compatibility of hydrogel were studied. The results show that BEO@Zein forms a nano-spherical structure with BEO as core and Zein as shell (mean particle size is 56.3 nm), which significantly reduces the volatility of BEO. BEO@Zein/PVP-PVA hydrogel can release BEO slowly, thus exhibiting excellent slow-release antibacterial property. Therefore, BEO@Zein/PVP-PVA hydrogel has excellent antimicrobial persistence (over 72 h). In addition, the hydrogel shows remarkable antibacterial biofilm property. BEO@Zein/PVP-PVA hydrogel has good mechanical property, swelling and moisturizing, degradability, and blood compatibility. Studies have shown that BEO@Zein/PVP-PVA hydrogel can be used as a good wound dressing material.
- wound dressing,
- antibacterial activity,
- Basil essential oil nanoparticles,
- nanoprecipitation method,
- hydrogel
Long Abstrsct
Innovation Points

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References(26)

References

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